Phage treatment and wetland technology

as intervention strategy to prevent dissemination of antibiotic resistance in surface waters.

Duration: 3 years
Start date: Feb. 1st 2022
End date: Jan. 31st 2025


Join Transnational Call for Proposals 2021

“One Health interventions to prevent or reduce the development and transmission of antimicrobial resistance”.


PhageLand aims to develop a novel intervention stategy

Combining the low-cost and eco-friendly purification capacity of passive treatment systems, namely constructed wetlands (CW), with a dedicated phage-based treatment to prevent the transmission of antibiotic resistance (AR) from wastewater into surface waters.

PhageLand includes public health investigations targeting multidrug-resistant bacterial (ARB) pathogens in low-middle income countries (LMICs) in Eastern Europe. The phage-based treatment will be specifically tailored to eliminate these multidrug-resistant pathogens from wastewater. In parallel, PhageLand aims to assess: a) the self-purification capacity of model full-scale CWs operating in Spain and Moldova in removing antibiotic residues, ARB and antibiotic resistance genes (ARGs); and b) the potential risk associated with the dissemination of ARB and ARGs within indigenous bacterial communities and among animals inhabiting CWs.


Experimental tasks will include field and laboratory experiments

Involving cutting-edge chemical, biotechnological and (meta)genomic techniques as well as animal testing.


Graphical abstract